The crash happened around 5:30 p.m. in the Tremont community on U.S. 119.
Andrea Joseph, 25, was traveling south, when her tires went off the side of the road, police said.
They said Joseph tried to get back onto the road, but over corrected.
She ran into a guardrail on the northbound side of the highway, they said.
The Harlan County coroner pronounced her dead at the scene.